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Reduced dosages of antihypertensives may be required during heavy sedation. The presence of 10 stereospecific carbons and several points of distinct substitution has made the total synthesis of erythromycin A a formidable task. In addition, growth-hormone deficient women also treated with estrogen replacement therapy require substantially more somatropin therapy to obtain comparable effects when compared to women not taking estrogen. Griseofulvin is used to treat fungal infections of your hair, nails, and skin. Exelon owns and operates a fossil generation portfolio of nearly 10,000 megawatts (MW). C avg = Average serum concentration; t 1/2 = Terminal elimination half-life.