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Among those are cancer (breast, ovarian), heart attack, stroke, and blood clots. Studies in lactating rats given a single oral dose of 1 mg/kg of [2-14C]-doxazosin indicate that doxazosin accumulates in rat breast milk with a maximum of concentration about 20 times greater than the maternal plasma concentration. For persons 35 and older, in addition to monthly symptom reviews, hepatic enzymes (specifically, AST and ALT [formerly SGOT and SGPT, respectively]) should be measured prior to starting isoniazid therapy and periodically throughout treatment. A 2-year study was performed in rats to evaluate the carcinogenic potential of naproxen at rat doses of 8, 16, and 24 mg/kg/day (50, 100, and 150 mg/m 2). If your doctor tells you to stop taking Co-Diovan, or it has passed its expiry date, ask your pharmacist what to do with any tablets that are left over. The risk or severity of adverse effects can be increased when Phenytoin is combined with Triprolidine.