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The serum concentration of Simvastatin can be increased when it is combined with Tadalafil. Surpass wants you to succeed with your projects and businesses. Benzodiazepines: Use with caution. The risk or severity of adverse effects can be increased when Ibuprofen is combined with Magnesium salicylate. Blood pressure response is dose-related over the range of 20 to 80 mg [see Clinical Studies (14. Kawarai T, Kawakami H, Yamamura Y, Nakamura S.