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Spasticity, involuntary movement, and cognitive retardation as well as manifestations of gout are seen in this syndrome. Although no definite pattern of teratogenicity and no causal association have been established from these cases, five of the reports describe the rare birth defect category, holoprosencephaly (defects associated with incomplete midline development of the forebrain). The risk or severity of adverse effects can be increased when Doxazosin is combined with Isosorbide Dinitrate. Do not crush, chew, break, or cut the tablet. Ragnarsson J, Hardarson T, Snorrason SP “Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. Tell your doctor if this happens.