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There is also a potential pharmacokinetic interaction with quinidine due to the fact that clomipramine is metabolised by CYP2D6 in vivo), diuretics (due to the potential for hypokalaemia (low blood potassium) to develop which increases the risk for QT interval prolongation and torsades de pointes), the selective serotonin reuptake inhibitors (SSRIs; due to both potential additive serotonergic effects leading to serotonin syndrome and the potential for a pharmacokinetic interaction with the SSRIs that inhibit CYP2D6 [e. Participants also tolerated the drug well. The serum concentration of Protriptyline can be increased when it is combined with Sitagliptin. The metabolism of Sitagliptin can be decreased when combined with Ziprasidone. Pentoxifylline may increase the anticoagulant activities of Rosiglitazone. Poster #64 from Proceedings of the 38th Annual Infectious Disease Society of America Meeting; September 7–10, 2000, New Orleans, La.