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The inhibition of the RAAS system causes an overall decrease in blood pressure. The risk or severity of adverse effects can be increased when Mesalazine is combined with Prednicarbate. The usual dosage of CANASA В® (mesalamine, USP) 1000 mg suppositories is one rectal suppository 1 time daily at bedtime. The metabolism of Chlorphenamine can be decreased when combined with Paroxetine. Store below 25В°C in airtight containers and protect from light. Life-threatening pancreatitis has been reported in both children and adults receiving valproate.