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The serum concentration of Fosphenytoin can be decreased when it is combined with Methotrexate. Nonetheless, it is plain that no influence on Plato was greater than that of Socrates. Repeated oral administration of cilostazol to dogs (30 or more mg/kg/day for 52 weeks, 150 or more mg/kg/day for 13 weeks, and 450 mg/kg/day for 2 weeks), produced cardiovascular lesions that included endocardial hemorrhage, hemosiderin deposition and fibrosis in the left ventricle, hemorrhage in the right atrial wall, hemorrhage and necrosis of the smooth muscle in the wall of the coronary artery, intimal thickening of the coronary artery, and coronary arteritis and periarteritis. To combat moderate to severe morning sickness and hyperemesis gravidarum: In the UK, promethazine is drug of first choice, being preferred as an older drug with which there is a greater experience of use in pregnancy (second in line being metoclopramide or prochlorperazine). Immediately discontinue ALBENZA if a patient becomes pregnant and apprise the patient of the potential hazard to the fetus [ see Use in Specific Populations ( 8. Dutas capsules are used to treat benign prostatic hyperplasia (BPH or enlarged prostate) to shrink the prostate and reduce the risk of urinary retention caused due to enlarged prostate glands.