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It may also enhance the blood pressure-increasing effects of sympathomimetic drugs such as pseudoephedrine or phenylpropanolamine. Alclometasone may increase the fluid retaining activities of Danazol. Blood vessels that become blocked in this way can lead to further heart disease, angina or stroke. Lonergan E, Luxenberg J (2009). In that case, I suggest that the family goes for counseling. The risks of lactic acidosis, its symptoms, and conditions that predispose to its development, as noted in the WARNINGS and PRECAUTIONS sections, should be explained to patients.