Prozac Pharmacology, Pharmacokinetics, Studies, Metabolism”. Posaconazole is a potent inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of ivermectin. Your doctor has prescribed this cream for your skin condition, rosacea. Tretinoin Cream, USP (Emollient) does not remove wrinkles or repair sun-damaged skin. Diclofenac, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Generic Proscar in combination with the alpha-blocker doxazosin is used to reduce the risk of symptomatic progression of BPH.