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Therefore, urinary supersaturation is a second potential surrogate endpoint for clinical trials. I took it a few hours after I ate dinner. The risk or severity of adverse effects can be increased when Phenazocine is combined with Amiloride. Simvastatin also interacts with other drugs, including some used to treat cardiovascular problems. Hydrochlorothiazide is also used to treat fluid retention ( edema) that is caused by congestive heart failure, severe liver disease ( cirrhosis), kidney disease, or treatment with a steroid or hormone medicine. BMC Complement Altern Med.