A number of entrepreneurs have been involved in efforts to gain approval to sell deprenyl for extending the lives of dogs, cats and other pets. Mephobarbital is a CYP3A4 inducer; prednisolone is a CYP3A4 substrate. Your doctor may start you on a low dose of imipramine and gradually increase your dose. Amazingly, when ashwagandha was administered to chronically stressed animals, the number of degenerating brain cells was reduced by 80%! Overdose – This medicine is available in the market in various dosage forms. The serum concentration of Fludrocortisone can be increased when it is combined with Itraconazole.