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As a specific and potent calcium antagonist, nifedipine acts particularly on the cells of the myocardium and the smooth muscle cells of the coronary arteries and the peripheral resistance vessels. How to tell if the drug is working: You may be able to tell this drug is working for benign prostatic hyperplasia (BPH) if you have an easier time urinating and experience fewer symptoms of obstruction and irritation. Please help by spinning off or relocating any relevant information, and removing excessive detail that may be against Wikipedia’s inclusion policy. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus. Administered at the start of a light meal. The risk or severity of adverse effects can be increased when Pizotifen is combined with Valproic Acid.