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Estrone levels are also low but may be slightly higher in in obese children after adrenarche develops. The serum concentration of Telaprevir can be decreased when it is combined with Prednisone. There are, however, no adequate and well-controlled studies of Acarbose in pregnant women. Hypersensitivity reactions including urticaria and angioedema have been reported [see Adverse Reactions (6. Williamson J, Russell F, Doig WM, Paterson RW. Evidence of a risk during pregnancy is equivocal; some authorities recommend that pregnant women limit consumption to the equivalent of two cups of coffee per day or less.