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Archived from the original on 2016-08-18 . If you have more severe depression, your doctor may prescribe you 375 mg per day. Hormonal contraceptives may also cause fluid retention, and patients predisposed to complications from edema should be closely monitored. Between 1988-1999, an EMS outbreak prompted the FDA to recall and cease over-the-counter tryptophan supplements. The metabolism of Palonosetron can be decreased when combined with Terbinafine. Guaifenesin; Phenylephrine: (Moderate) The cardiovascular effects of sympathomimetics may reduce the antihypertensive effects produced by diuretics.