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Metoprolol may increase the hypotensive activities of Bimatoprost. British National Formulary (BNF) 65. Metformin half-life is unaffected. New Drug Tempting Dieters, But Experts Debate Hoodia’s Merits”. Swallow the extended-release and regular tablets whole; do not chew or crush them. In controlled monotherapy trials of hypertensive patients, BYSTOLIC was associated with an increase in BUN, uric acid, triglycerides and a decrease in HDL cholesterol and platelet count.