The risk or severity of adverse effects can be increased when Cetirizine is combined with Dantrolene. Do not take more than the recommended dose, as this may be harmful, including the risk of liver damage. Painful urination can also indicate renal failure or damage. The side effects should go away after a few hours. The serum concentration of Imipramine can be increased when it is combined with Aprotinin. In the past, EE was widely used alone for various indications such as the treatment of gynecological disorders and prostate cancer, but this is no longer the case.