Close your eye and press lightly against the lower lid with your finger for 2 to 3 minutes to keep the medication in the eye. Ask your doctor if glipizide is right for you. Caution is advised when administering diclofenac to patients with mild to moderate hepatic impairment (see section 4. Bupropion, when used for treating obesity over a period of 6 to 12 months, may result in weight loss of 2. However, potential benefits of clonidine may outweigh the possible risks in a rare obstetrical, post-partum, or perioperative patient. The mean improvements over baseline in the clinical signs at the end of treatment are shown in Table 4.