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The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of clomipramine. The risk or severity of adverse effects can be increased when Haloperidol is combined with Clidinium. Fluconazole has also rarely been associated with severe or lethal hepatotoxicity, so liver function tests are usually performed regularly during prolonged fluconazole therapy. Metabolism is by oxidative biotransformation, it is hepatic and complete. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December 2004. Guggul herb or Guggulu herbal cure is very helpful to maintain lipid metabolism which helps to control the weight and also reduces the fats in the body.