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Consider doubling the rifabutin dose in regimens where rifabutin is given 2 or 3 times a week. Cialis has a very efficient profile for men of all ages. Oral contraceptives should be discontinued if there is unexplained partial or complete loss of vision; onset of proptosis or diplopia; papilledema; or retinal vascular lesions. The systemic azoles developed after ketoconazole include fluconazole, itraconazole, voriconazole and posaconazole. Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with increased risk of Clostridium difficile-associated diarrhea. Norfloxacin is also considered to be contraindicated within the pediatric population.