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Meanwhile, HYDRA’s sleeper agents in other S. For male and female rats, 500 mg/kg/day provided an average systemic exposure to irbesartan (AUC 0–24 hour, bound plus unbound) about 3 and 11 times, respectively, the average systemic exposure in humans receiving the maximum recommended dose (MRD) of 300 mg irbesartan/day, whereas 1000 mg/kg/day (administered to females only) provided an average systemic exposure about 21 times that reported for humans at the MRD. Sodium phosphate may increase the nephrotoxic activities of Indomethacin. Coca-Cola, caffeine, and mental deficiency: Harry Hollingworth and the Chattanooga trial of 1911″. Prednisone is used to treat rheumatoid arthritis, lupus, vasculitis, and many other inflammatory diseases. The Australian and New Zealand Journal of Psychiatry.